Adipogen/anti-TLR3 (human), mAb (ABM15D5)/AG-20T-0301-C100/100 µg

来自 : 发布时间：2024-12-23

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Toll-like Receptor 3; CD283

Monoclonal Antibody

ABM15D5

Mouse IgG1κ

Recombinant human TLR3 protein (aa 25-370).

Flow Cytometry: (2μg/106 cells)Western Blot: (2-4μg/ml)Optimal conditions must be determined individually for each application.

Human

Recognizes human TLR3.

Protein G purified.

0.5mg/ml

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

O15455

BLUE ICE

+4°C

-20°C

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.Stable for at least 6 months after receipt when stored at +4°C.

No

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TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.